Educational activities of the Nirmala Charitable Trust was started in the year 1956 with functioning of a primary school at Thalacode in Chottanikkara panchayat, which was a very undeveloped locality at that time.
The founder of the trust Very Rev. O.C. Kuriakose Kor-Episca was a great visionary. He wanted to have pre-primary to higher education institutions under the Trust.
Nirmala Arts and Science College, Mulanthuruthy was started in the year 2007 with 2 undergraduate courses – B Com( Finance and Taxation) and BBA. The main block of the college building was consecrated by , H.G. Dr. Mathews Mar Severiose, Metropolitan of Kandanad and Patron of the College on the 13th of July 2007
In 2009, B Com Computer Applications was started in the college
Department of Computer Applications and M.Com (Master of Commerce) was started in college
In 2013 BA ( Communicative English II ) main course was sanctioned. On August 13th 2013, the college witnessed the cosecration of the auditorium.
Prof. N.O Daisy took over as the principal in 2016 after the exemplary service of Prof. V.G Remanan. The college started its effort for achieving NAAC accreditation.
The month of July and August in 2018. The college opened up a flood relief camp to serve nearly 200 affected families. Dr. C.A Geetha succeeded Prof. N.O Daisy as the principal in the year 2018. Prof. N.O daisy is currently the college dean.
In 2019 B Sc. Psychology course was also sanctioned in the college. For further development of the activities of the college, construction work of an annex building was started in the year 2019.